International Recognition

Published abstract

EDM 2026 Program Abstract

Obesity is a chronic, relapsing, and multifactorial metabolic disease that remains a major contributor to global morbidity and mortality. The emergence of incretin-based therapies, particularly glucagon-like peptide-1 (GLP-1) receptor agonists and dual GLP-1/GIP agonists, has significantly advanced obesity treatment, demonstrating substantial weight loss, improved glycemic control, and favorable cardiometabolic outcomes. However, long-term success remains limited by weight regain, lean mass loss, and incomplete metabolic restoration.

This presentation proposes an integrative, physiology-driven framework that combines GLP-1–based pharmacotherapy with hormone optimization and longevity-focused interventions to address the underlying drivers of metabolic dysfunction. Key endocrine pathways—including insulin signaling, hypothalamic-pituitary-adrenal (HPA) axis regulation, thyroid function, and sex hormone balance—are evaluated for their roles in energy homeostasis, adiposity, and metabolic resilience.

Adjunctive strategies are explored to enhance treatment sustainability, including preservation of lean muscle mass, optimization of mitochondrial function, and reduction of chronic low-grade inflammation. Nutritional interventions, resistance training, and targeted peptide therapies are discussed as essential components in mitigating adverse effects associated with GLP-1 therapy and improving long-term outcomes.

Clinical protocols, patient selection criteria, and safety considerations are highlighted, with emphasis on individualized treatment plans and prevention of post-therapy weight regain. Insights from real-world clinical practice demonstrate the feasibility of integrating these modalities within a physician-led metabolic and wellness setting.

By bridging incretin-based pharmacotherapy with endocrinology and longevity medicine, this model provides a comprehensive and sustainable approach to obesity management, with the potential to enhance metabolic health, improve body composition, and extend health span.